The effect of natural adjuvants (G2, G2F) on lung inflammation of sensitized guinea pigs

Authors

  • Ali Neamati Department of Biology, Faculty of Science, Islamic Azad University, Mashhad Branch, I. R. Iran
  • Mohammad Hossein Boskabady Applied Physiology Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
  • Mohammad Reza Khakzad Islamic Azad University, Mashhad Branch, and Zakaria Reserch Center, Mashhad, I. R. Iran
  • Saleh Mohaghegh Hazrati School of Public Health, Tehran University of Medical Sciences and Researches on Industrial Biotechnology, Tehran, I. R. Iran
  • Shakeeb Hassan Moosavi Faculty of Medicine, NHLI, Imperial College, London, UK
Abstract:

Objective: The effects of natural adjuvants were examined on total and differential WBC counts in lung lavage of sensitized guinea pigs. Materials and Methods: In three sensitized groups of guinea pigs including: untreated sensitized animals (S), sensitized animals treated with adjuvant G2 (S+G2) and G2F (S+G2F) as well as non-sensitized group (C) (n=6 for each group), total and differential WBC counts of lung lavage were examined. Sensitization of animals was achieved by injection and inhalation of ovalbumin (OA). Results: The results showed increased total WBC, eosinophil, neutrophil, and basophil counts, and decreased lymphocytes in lung lavage of sensitized animals compared with the control group (pConclusion: These results indicate important preventive effects of two natural adjuvants, especially G2, on lung inflammation of sensitized guinea pigs.  

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Journal title

volume 3  issue 4

pages  364- 370

publication date 2013-09-01

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